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'Nature genetics'에 해당되는 글 1건
2011. 7. 4. 09:30

연구소 네이처 논문중에 처음으로 Author에 이름을 올린 논문!! 비록 지금은 중간이지만 언젠가는...


Abstract

Massively parallel sequencing technologies have identified a broad spectrum of human genome diversity. Here we deep sequenced and correlated 8 genomes and 7 transcriptomes of unrelated Korean individuals. This has allowed us to construct a genomewide map of common and rare variants and also identify variants formed during DNA-RNA transcription. We identified 9.56

million genomic variants, 23.2% of which appear to be previously unidentified. From transcriptome sequencing, we discovered 4,44 transcripts not previously annotated. Finally, we revealed ,809 sites of transcriptional base modification, where the transcriptional landscape is different from the corresponding genomic sequences, and 580 sites of allele-specific expression. Our findings suggest that a considerable number of unexplored genomic variants still remain to be identified in the human genome, and that the integrated analysis of genome and transcriptome sequencing is powerful for understanding the diversity and functional aspects of human genomic variants.

 
NG : http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.872.html


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